Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth| differentiation| mitotic cycle| and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains| which act as protein phospho-tyrosine binding domains| and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells| and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with| and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene| which encode distinct isoforms| have been reported.

Classification:

Primary antibody

Alternative names:

Tyrosine-protein phosphatase non-receptor type 6; PTPN6; HCP; PTP1C; Tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human SHP-1 around the phosphorylation site of Tyr536. AA range:502-551

Concentration:

1 mg/ml

Molecular weight:

67561

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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