Background:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active| hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB)| bladder cancer| and osteogenic sarcoma.

Classification:

Primary antibody

Alternative names:

Retinoblastoma-associated protein; RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser807. AA range:781-830

Concentration:

1 mg/ml

Molecular weight:

106159

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com