Background:

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K)| which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated| the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2| which in turn phosphorylate to activate the serine/threonine specific protein kinases| ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle| apoptosis| cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Classification:

Primary antibody

Alternative names:

RAF proto-oncogene serine/threonine-protein kinase; RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human C-RAF around the phosphorylation site of Ser296. AA range:271-320

Concentration:

1 mg/ml

Molecular weight:

73052

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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