Background:

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration| nicotinic acetylcholine receptor activation| membrane depolarization| or protein kinase C activation. This protein has been shown to bind CRK-associated substrate| nephrocystin| GTPase regulator associated with FAK| and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity t

Classification:

Primary antibody

Alternative names:

Protein-tyrosine kinase 2-beta; PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PYK2 around the phosphorylation site of Tyr881. AA range:847-896

Concentration:

1 mg/ml

Molecular weight:

115875

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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