Background:

The protein encoded by this gene catalyzes the formation of inositol 1|4|5-trisphosphate and diacylglycerol from phosphatidylinositol 4|5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example| when activated by SRC| the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi| where it activates Ras. Also| this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-1; PLCG1; PLC1; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1

Species reactivity:

Human, Mouse, Rat, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PLCG1 around the phosphorylation site of Tyr771. AA range:736-785

Concentration:

1 mg/ml

Molecular weight:

148532

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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