Background:

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation| differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent| PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore| it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes| it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to| but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Classification:

Primary antibody

Alternative names:

Protein kinase C zeta type; PRKCZ; PKC2; Protein kinase C zeta type; nPKC-zeta

Species reactivity:

Human, Mouse, Rat, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PKC zeta around the phosphorylation site of Thr560. AA range:526-575

Concentration:

1 mg/ml

Molecular weight:

67660

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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