Background:

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|Phosphorylates and activates not only PKB/AKT| but also PKA| PKC-zeta| RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.|PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241| leading to its own activation.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.|Contains 1 PH domain.|Contains 1 protein kinase domain.|subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.|subunit:Interacts with TUSC4.|tissue specificity:Appears to be expressed ubiquitously.|

Classification:

Primary antibody

Alternative names:

3-phosphoinositide-dependent protein kinase 1; PDPK1; PDK1; 3-phosphoinositide-dependent protein kinase 1; hPDK1

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PDK1 around the phosphorylation site of Ser241. AA range:210-259

Concentration:

1 mg/ml

Molecular weight:

63152

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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