Background:

There are approximately 40 known eukaryotic LIM proteins| so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA| the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK| a downstream effector of Rho| and the encoded protein| in turn| phosphorylates cofilin| inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

LIM domain kinase 2; LIMK2; LIM domain kinase 2; LIMK-2

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phospho-peptide around the phosphorylation site of human LIMK-2 (phospho Thr505)

Concentration:

1 mg/ml

Molecular weight:

72232

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

More info:

Email: info@sobekbio.com

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