Background:

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation| a PTK domain| and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs| respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles| and binds to cell surface receptors| including CD4 and CD8| and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.

Classification:

Primary antibody

Alternative names:

Tyrosine-protein kinase Lck; LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Lck around the phosphorylation site of Tyr505. AA range:460-509

Concentration:

1 mg/ml

Molecular weight:

58001

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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