Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits| large and small| that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7| and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome| non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Classification:

Primary antibody

Alternative names:

Caspase-10 p23/17 ;Cleaved-D415; Caspase-10; CASP-10; EC 3.4.22.63; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; Caspase-10 subunit p23/17; Caspase-10 subunit p12;

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human Caspase-10 p23/17 (Cleaved-D415)

Concentration:

1 mg/ml

Molecular weight:

57310

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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