Background:

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis| the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability| chromatin structure and gene expression. Vertebrate lamins consist of two types| A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy| familial partial lipodystrophy| limb girdle muscular dystrophy| dilated cardiomyopathy| Charcot-Marie-Tooth disease| and Hutchinson-Gilford progeria syndrome.

Classification:

Primary antibody

Alternative names:

Prelamin-A/C; LMNA; LMN1; Prelamin-A/C

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Lamin A/C around the phosphorylation site of Ser392. AA range:361-410

Concentration:

1 mg/ml

Molecular weight:

74139

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com