Background:

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II)| aspartate transcarbamoylase| and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade| which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Classification:

Primary antibody

Alternative names:

CAD ;Ser1859 ; CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase; EC 6.3.5.5; Aspartate carbamoyltransferase; EC 2.1.3.2; Dihydroorotase; EC 3.5.2.3;

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human CAD (Ser1859)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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