Background:

The protein encoded by this gene is a bifunctional| cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high| this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low| the protein binds to iron-responsive elements (IREs)| which are stem-loop structures found in the 5' UTR of ferritin mRNA| and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE| it results in repression of translation of ferritin mRNA| and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct

Classification:

Primary antibody

Alternative names:

Cytoplasmic aconitate hydratase; ACO1; IREB1; Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1

Species reactivity:

Human, Mouse, Rat, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human IREB1 around the phosphorylation site of Ser711. AA range:681-730

Concentration:

1 mg/ml

Molecular weight:

98399

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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