Background:

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses| one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases| which localize to the mitochondrial matrix| and two NADP(+)-dependent isocitrate dehydrogenases| one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

IDHP; Isocitrate dehydrogenase [NADP; ; mitochondrial; IDH; EC 1.1.1.42; ICD-M; IDP; NADP;+-specific ICDH; Oxalosuccinate decarboxylase

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human IDHP

Concentration:

1 mg/ml

Molecular weight:

Applications:

IHC-p, IF, WB

Storage:

-20°C for 1 year

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