Background:

Histones play a critical role in transcriptional regulation| cell cycle progression| and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Classification:

Primary antibody

Alternative names:

Histone deacetylase 3; HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human HDAC3 around the phosphorylation site of Ser424. AA range:379-428

Concentration:

1 mg/ml

Molecular weight:

48848

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

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