Background:

Histone acetylation and deacetylation| catalyzed by multisubunit complexes| play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2| it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Classification:

Primary antibody

Alternative names:

Histone deacetylase 1; HDAC1; RPD3L1; Histone deacetylase 1; HD1

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human HDAC1 around the phosphorylation site of Ser421. AA range:387-436

Concentration:

1 mg/ml

Molecular weight:

55103

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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