Background:

This gene encodes glucocorticoid receptor| which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription| and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm| but upon ligand binding| is transported into the nucleus. It is involved in inflammatory responses| cellular proliferation| and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described| and shown to be functional| displaying diverse cytoplasm-to-nucleus trafficking pat

Classification:

Primary antibody

Alternative names:

Glucocorticoid receptor; NR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human GR around the phosphorylation site of Ser211. AA range:181-230

Concentration:

1 mg/ml

Molecular weight:

85659

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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