Background:

Intact BH3 motif is required by BIK| BID| BAK| BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1| isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.|PTM:Phosphorylated upon DNA damage| probably by ATM or ATR.|PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.|subcellular location:A significant proportion of isoform 2 localizes to mitochondria| it may be cleaved constitutively.|subcellular location:Associated with the mitochondrial membrane.|subcellular location:Translocates to mitochondria as an integral membrane protein.|subcellular location:When uncleaved| it is predominantly cytoplasmic.|subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.|tissue specificity:Isoforms 2 and 3 are expressed in spleen| bone marrow| cerebral and cerebellar cortex. Isoform 2 is expressed in spleen| pancreas and placenta (at protein level). Isoform 3 is expressed in lung| pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).|

Classification:

Primary antibody

Alternative names:

BID ;Cleaved-Arg71; BH3-interacting domain death agonist; p22 BID; BID; BH3-interacting domain death agonist p15; p15 BID; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID;

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human BID (Cleaved-Arg71)

Concentration:

1 mg/ml

Molecular weight:

21450

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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