Background:

disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.|disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.|disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.|Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.|induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS| CD40L and zymosan.|PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.|Contains 1 BTB (POZ) domain.|Contains 6 C2H2-type zinc fingers.|subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.|tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.|

Classification:

Primary antibody

Alternative names:

Bcl-6 ;Acetyl Lys379; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human Bcl-6 (Acetyl Lys379)

Concentration:

1 mg/ml

Molecular weight:

77660

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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