Background:

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition| the enzyme may be involved in regulation of transcription| regulation of cell cycle and growth| response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS)| which involves increased risk of cancers including malignant mesothelioma| uveal melanoma and cutaneous melanoma.

Classification:

Primary antibody

Alternative names:

BAP1 ;Ser592; Ubiquitin carboxyl-terminal hydrolase BAP1; EC 3.4.19.12; BRCA1-associated protein 1; Cerebral protein 6

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human BAP1 (Ser592)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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