Background:

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants| at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques| which accumulate in the brains of human Alzheimer's disease patients.

Classification:

Primary antibody

Alternative names:

BACE ;Phospho Ser498; Beta-secretase 1; EC 3.4.23.46; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human BACE (Phospho Ser498)

Concentration:

1 mg/ml

Molecular weight:

55110

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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