Background:

The protein encoded by this gene is a member of the immunophilin protein family| which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels| and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse| deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants| encoding the same protein| have been identified. The human genome contains five pseudogenes related to this gene| at least one of which is transcribed.

Classification:

Primary antibody

Alternative names:

FKBP1A/B

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human FKBP1A/B

Concentration:

1 mg/ml

Molecular weight:

Applications:

IHC-p, IF, WB

Storage:

-20°C for 1 year

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