Background:

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins| transmembrane receptor complexes| and second messengers. Defects in this gene are a cause of several syndromes| including periventricular nodular heterotopias (PVNH1| PVNH4)| otopalatodigital syndromes (OPD1| OPD2)| frontometaphyseal dysplasia (FMD)| Melnick-Needles syndrome (MNS)| and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

Filamin-A; FLNA; FLN; FLN1; Filamin-A; FLN-A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin

Species reactivity:

Human, Mouse, Rat, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Filamin A around the phosphorylation site of Ser2152. AA range:2121-2170

Concentration:

1 mg/ml

Molecular weight:

280608

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com