Background:

The Fanconi anemia complementation group (FANC) currently includes FANCA| FANCB| FANCC| FANCD1 (also called BRCA2)| FANCD2| FANCE| FANCF| FANCG| FANCI| FANCJ (also called BRIP1)| FANCL| FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability| hypersensitivity to DNA crosslinking agents| increased chromosomal breakage| and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage| resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repai

Classification:

Primary antibody

Alternative names:

Fanconi anemia group D2 protein; FANCD2; FACD; Fanconi anemia group D2 protein; Protein FACD2

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human FANCD2 around the phosphorylation site of Ser222. AA range:188-237

Concentration:

1 mg/ml

Molecular weight:

166462

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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