Background:

The Fanconi anemia complementation group (FANC) currently includes FANCA| FANCB| FANCC| FANCD1 (also called BRCA2)| FANCD2| FANCE| FANCF| FANCG| FANCI| FANCJ (also called BRIP1)| FANCL| FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability| hypersensitivity to DNA crosslinking agents| increased chromosomal breakage| and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.

Classification:

Primary antibody

Alternative names:

Fanconi anemia group A protein; FANCA; FAA; FACA; FANCH; Fanconi anemia group A protein; Protein FACA

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human FANCA around the phosphorylation site of Ser1149. AA range:1121-1170

Concentration:

1 mg/ml

Molecular weight:

162775

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

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