Background:

The protein encoded by this gene belongs the PI3/PI4-kinase family| and is most closely related to ATM| a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3| a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1| checkpoint proteins RAD17| and RAD9| as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported| however| its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Classification:

Primary antibody

Alternative names:

ATR ;Thr1989; Serine/threonine-protein kinase ATR; EC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phosho peptide around human ATR (Thr1989)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB

Storage:

-20°C for 1 year

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