Background:

The Fas associated via death domain encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain| this protein can be recruited by TNFRSF6/Fas-receptor| tumor necrosis factor receptor| TNFRSF25| and TNFSF10/TRAIL-receptor| and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein| which allows it to recruit caspase-8| and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Classification:

Primary antibody

Alternative names:

Protein FADD; FADD; MORT1; GIG3; Protein FADD; FAS-associated death domain protein; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity

Species reactivity:

Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from mouse FADD around the phosphorylation site of Ser191. AA range:157-206

Concentration:

1 mg/ml

Molecular weight:

23279

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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