Background:

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation| promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA| EIF2| and GTP. EIF2 is composed of 3 nonidentical subunits| the 36-kD EIF2-alpha subunit (EIF2S1)| the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908)| and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al.| 1987

Classification:

Primary antibody

Alternative names:

Eukaryotic translation initiation factor 2 subunit 1; EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human eIF2 alpha around the phosphorylation site of Ser51. AA range:21-70

Concentration:

1 mg/ml

Molecular weight:

36112

Applications:

IF, ICC, WB, IHC-p, ELISA

Storage:

-20°C for 1 year

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