Background:

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants| at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats| a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric| breast| colorectal| thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation| invasion| and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

Classification:

Primary antibody

Alternative names:

Cadherin-1; CDH1; CDHE; UVO; Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD antigen CD324; CDH2; CDHN; NCAD; Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD antigen CD325; CDH3; CDHP; Cadherin-3; Placental cadherin; P-cadhe

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Cadherin. AA range:833-882

Concentration:

1 mg/ml

Molecular weight:

97456;99809;91418;100281

Applications:

WB, IHC-p, IF, ICC, ELISA

Storage:

-20°C for 1 year

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