Background:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK| SAPK/JNK| p38)| which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases| different tissue distribution and subcellular localization| and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1| ERK2 and JNK| is expressed in a variety of tissues| and is localized in the nucleus. Two alternatively spliced transcript variants| encoding distinct isoforms| have been obser

Classification:

Primary antibody

Alternative names:

Dual specificity protein phosphatase 4;EC 3.1.3.16;EC 3.1.3.48;Dual specificity protein phosphatase hVH2;Mitogen-activated protein kinase phosphatase 2;MAP kinase phosphatase 2;MKP-2; Dual specificity protein phosphatase 4; EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase hVH2; Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human DUSP4 Polyclonal

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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