Background:

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions| which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia| autosomal recessive craniometaphyseal dysplasia and heart malformations.

Classification:

Primary antibody

Alternative names:

Gap junction alpha-1 protein; GJA1; GJAL; Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Connexin 43 around the phosphorylation site of Ser367. AA range:332-381

Concentration:

1 mg/ml

Molecular weight:

43008

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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