Background:

The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins| that are also known as anoctamins. While little is known about the function of this gene| mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with| and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms.

Classification:

Primary antibody

Alternative names:

ANO3

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human ANO3

Concentration:

1 mg/ml

Molecular weight:

107910

Applications:

WB

Storage:

-20°C for 1 year

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