Background:

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family| the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein| which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons| functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization| endocytosis and exocytosis| and apoptosis. In humans| an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

Cyclin-dependent kinase 5; CDK5; CDKN5; Cyclin-dependent kinase 5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit

Species reactivity:

Human, Mouse, Rat, Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CDK5 around the phosphorylation site of Tyr15. AA range:1-50

Concentration:

1 mg/ml

Molecular weight:

33304

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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