Background:

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage| which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene| although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

M-phase inducer phosphatase 1; CDC25A; M-phase inducer phosphatase 1; Dual specificity phosphatase Cdc25A

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phospho-peptide around the phosphorylation site of human Cdc25A (phospho Ser75)

Concentration:

1 mg/ml

Molecular weight:

59087

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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