Background:

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia| an autosomal recessive disorder.

Classification:

Primary antibody

Alternative names:

ATM; ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized phospho-peptide around the phosphorylation site of human Atm (phospho Ser1981)

Concentration:

1 mg/ml

Molecular weight:

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for 1 year

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