Background:

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain| DNA-binding domain| and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand| the receptor dissociates from accessory proteins| translocates into the nucleus| dimerizes| and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform

Classification:

Primary antibody

Alternative names:

Androgen receptor; AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Androgen Receptor. AA range:331-380

Concentration:

1 mg/ml

Molecular weight:

98989

Applications:

WB, ELISA

Storage:

-20°C for 1 year

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