Background:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD)| which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes| including cell cycle progression| signal transduction| apoptosis| and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms.

Classification:

Primary antibody

Alternative names:

IF122

Species reactivity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human IF122

Concentration:

1 mg/ml

Molecular weight:

136510

Applications:

WB

Storage:

-20°C for 1 year

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