Background:

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Classification:

Primary antibody

Alternative names:

CAD; CAD protein

Species reactivity:

Human;mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CAD around the phosphorylation site of Thr456. AA range:422-471

Concentration:

1 mg/ml

Molecular weight:

242984

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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