Background:

CASP2 (caspase 2) encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of CASP2 may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for CASP2.

Classification:

Primary antibody

Alternative names:

CASP2; ICH1; NEDD2; Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Caspase 2 around the phosphorylation site of Ser157. AA range:123-172

Concentration:

1 mg/ml

Molecular weight:

50685

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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