Background:

APC encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Classification:

Primary antibody

Alternative names:

APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human APC around the phosphorylation site of Ser2054. AA range:2020-2069

Concentration:

1 mg/ml

Molecular weight:

311646

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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