Background:

Catenin beta-1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Classification:

Primary antibody

Alternative names:

CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin

Species reactivity:

Human;mouse;rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Catenin-beta around the phosphorylation site of Tyr654. AA range:620-669

Concentration:

1 mg/ml

Molecular weight:

85497

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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