Background:

CASP6 (caspase 6) encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.

Classification:

Primary antibody

Alternative names:

CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

Species reactivity:

Human;mouse;rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Caspase 6 around the phosphorylation site of Ser257. AA range:223-272

Concentration:

1 mg/ml

Molecular weight:

33310

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

More info:

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