Background:

ERCC5 encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. DNA repair protein complementing XP-G cells may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Classification:

Primary antibody

Alternative names:

ERCC5; ERCM2; XPG; XPGC; DNA repair protein complementing XP-G cells; DNA excision repair protein ERCC-5; Xeroderma pigmentosum group G-complementing protein

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human ERCC5. AA range:131-180

Concentration:

1 mg/ml

Molecular weight:

133307

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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