Background:

The protein encoded by TSG101 (tumor susceptibility 101) belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in TSG101 occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

Classification:

Primary antibody

Alternative names:

TSG101; Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101

Species reactivity:

Human;Mouse;Rat;Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human TSG101. AA range:281-330

Concentration:

1 mg/ml

Molecular weight:

43944

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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