Background:

TICAM1 (toll like receptor adaptor molecule 1) encodes an adaptor protein containing a Toll/interleukin-1 receptor(TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors(TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.

Classification:

Primary antibody

Alternative names:

TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-contai

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from TRIF at AA range: 663-712

Concentration:

1 mg/ml

Molecular weight:

76422

Applications:

WB, ELISA

Storage:

-20°C for one year

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