Background:

BCCIP (BRCA2 and CDKN1A interacting protein) product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for BCCIP.

Classification:

Primary antibody

Alternative names:

BCCIP; TOK1; BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; Protein TOK-1

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from TOK-1 . at AA range: 60-140

Concentration:

1 mg/ml

Molecular weight:

35979

Applications:

WB, ELISA

Storage:

-20°C for one year

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