Background:

Tumor necrosis factor receptor superfamily member 1B encoded by TNFRSF1B is a member of the TNF-receptor superfamily. Tumor necrosis factor receptor superfamily member 1B and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Classification:

Primary antibody

Alternative names:

TNFRSF1B; TNFBR; TNFR2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha rec

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human TNF Receptor II. AA range:376-425

Concentration:

1 mg/ml

Molecular weight:

48291

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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