Background:

TMEM173 encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The transmembrane protein 173 is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

TMEM173; ERIS; MITA; STING; Transmembrane protein 173; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Stimulator of interferon genes protein; hSTING

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from Transmembrane protein 173 at AA range: 301-350

Concentration:

1 mg/ml

Molecular weight:

42193

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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