Background:

TINF2 encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The TERF1 interacting nuclear factor 2 encoded by TINF2 is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.

Classification:

Primary antibody

Alternative names:

TINF2; TIN2; TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human TINF2. AA range:71-120

Concentration:

1 mg/ml

Molecular weight:

50023

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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