Background:

TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TIE1.

Classification:

Primary antibody

Alternative names:

TIE1; TIE; Tyrosine-protein kinase receptor Tie-1

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human TIE1. AA range:851-900

Concentration:

1 mg/ml

Molecular weight:

125090

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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